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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERN1
All Species:
13.94
Human Site:
Y517
Identified Species:
23.59
UniProt:
O75460
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75460
NP_001424.3
977
109735
Y517
L
L
D
T
S
G
P
Y
S
E
S
S
G
T
S
Chimpanzee
Pan troglodytes
XP_511585
968
108684
Y506
G
A
E
G
T
I
V
Y
R
H
N
S
R
S
S
Rhesus Macaque
Macaca mulatta
XP_001109583
1070
119711
Y610
L
L
D
T
S
G
P
Y
S
E
S
S
G
T
S
Dog
Lupus familis
XP_853409
975
109686
Y515
L
L
D
S
S
G
L
Y
S
E
S
S
G
T
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQY0
977
110166
F517
F
L
D
S
S
G
P
F
S
E
S
S
G
T
S
Rat
Rattus norvegicus
XP_573211
965
109012
F505
F
L
D
S
S
G
L
F
S
E
S
S
G
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510886
942
106736
L478
L
A
Q
D
P
D
F
L
D
V
A
T
C
G
H
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001085649
958
108223
T508
R
N
S
S
S
A
Q
T
L
F
F
S
E
D
Q
Zebra Danio
Brachydanio rerio
XP_001919350
921
102695
S478
L
N
T
P
P
S
T
S
S
Y
S
N
S
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097839
1074
120152
S494
A
L
F
W
Y
T
C
S
T
M
R
E
L
Q
K
Honey Bee
Apis mellifera
XP_392044
968
110555
N482
L
S
Q
G
S
R
E
N
N
S
T
S
D
Y
Y
Nematode Worm
Caenorhab. elegans
Q09499
967
109804
N492
A
Q
T
S
K
Q
S
N
R
G
S
F
G
W
A
Sea Urchin
Strong. purpuratus
XP_786178
1112
123199
G536
F
K
A
L
I
L
K
G
I
S
R
Q
K
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32361
1115
126957
K620
A
V
N
D
G
S
L
K
S
E
K
D
N
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.7
90.3
95.5
N.A.
93.1
92.1
N.A.
83
N.A.
56
57
N.A.
37.7
43
41.3
41.4
Protein Similarity:
100
84.8
91
97.3
N.A.
96.3
94.8
N.A.
89.3
N.A.
71.4
69.8
N.A.
52.9
58.6
59.3
54.4
P-Site Identity:
100
20
100
86.6
N.A.
80
73.3
N.A.
6.6
N.A.
13.3
20
N.A.
6.6
20
13.3
0
P-Site Similarity:
100
46.6
100
93.3
N.A.
93.3
86.6
N.A.
20
N.A.
20
33.3
N.A.
13.3
33.3
26.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
25.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
22
15
8
0
0
8
0
0
0
0
8
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
36
15
0
8
0
0
8
0
0
8
8
15
8
% D
% Glu:
0
0
8
0
0
0
8
0
0
43
0
8
8
0
0
% E
% Phe:
22
0
8
0
0
0
8
15
0
8
8
8
0
0
0
% F
% Gly:
8
0
0
15
8
36
0
8
0
8
0
0
43
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% H
% Ile:
0
0
0
0
8
8
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
8
0
8
8
0
0
8
0
8
0
8
% K
% Leu:
43
43
0
8
0
8
22
8
8
0
0
0
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
15
8
0
0
0
0
15
8
0
8
8
8
0
0
% N
% Pro:
0
0
0
8
15
0
22
0
0
0
0
0
0
8
0
% P
% Gln:
0
8
15
0
0
8
8
0
0
0
0
8
0
8
8
% Q
% Arg:
8
0
0
0
0
8
0
0
15
0
15
0
8
0
8
% R
% Ser:
0
8
8
36
50
15
8
15
50
15
50
58
8
15
43
% S
% Thr:
0
0
15
15
8
8
8
8
8
0
8
8
0
36
0
% T
% Val:
0
8
0
0
0
0
8
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
8
0
0
29
0
8
0
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _